What is an allergy Allergic diseases are the sixth largest chronic disease affecting 30-40% of the global population and have become an internationally recognized public health issue. How did such a severe allergy occur? Generally speaking, our bodies have; Protection Wall; To protect oneself. When harmful substances enter the human body, they trigger the immune system to attack; The enemy;. But when this response exceeds the normal range, the immune system will attack harmless substances, and this abnormal situation is called an allergic reaction, and allergies are a type of allergic reaction. “ No distinction between friend and foe; — — allergy Allergic reactions are often classified into type I (immediate type), type II (cytotoxic type), type III (immune complex type), and type IV (delayed type) in clinical practice. Allergy is the main representative of type I allergic reactions, which can be divided into allergic reactions and allergic diseases. The former is a systemic syndrome in which the body responds abnormally to allergens; The latter refers to allergies that affect specific organs and tissues, leading to the occurrence of a certain disease. When patients first come into contact with allergens, their bodies produce allergen specific IgE (sIgE). According to their existence status, sIgE can be divided into membrane-bound IgE that binds to mast cells (MC)/basophils (Bas) and secreted IgE that is free in serum. When the body comes into contact with allergens again, they bind to membrane-bound IgE, triggering a series of biochemical reactions on the cell membrane, leading to cell degranulation and the release of inflammatory mediators such as histamine, prostaglandins, leukotrienes, and trypsin.     Don't be careless! These allergic diseases are very commonIn the past decades, the incidence rate of allergic diseases has increased significantly, and it is estimated that more than 200 million people are suffering from allergic diseases in China. Common allergic diseases include allergic rhinitis, asthma, conjunctivitis, eczema, food allergies, drug allergies, and severe allergic reactions. Allergic diseases seriously affect the quality of life of children and adults, and even endanger their lives. For example, urticaria is an allergic skin manifestation characterized by episodic skin itching and the appearance of congested wheals. Severe patients may present with symptoms of anaphylactic shock such as palpitations, nausea and vomiting, difficulty breathing, laryngeal edema, and even decreased blood pressure. Allergen detection methodsIn vivo allergen testingSkin prick test (SPT)Intradermal Test (IDT)In vitro allergen testingSerum Total IgE (tIgE) DetectionSerum specific IgE (sIgE) detection     Why can Deheng Medicine leadGlobal allergen rapid detection technologySay goodbye to the tedious process of traditional testing, no need to endure the pain of skin tests, just draw a drop of blood from your fingertips, and you can quickly and accurately detect which substances you are allergic to. Common pollen, dust mites, and food can be accurately identified, allowing you to have a thorough understanding of your physical condition The core product of Deheng Medical Allergen Testing; Allergen specific IgE antibody assay kit; Adopting quantum dot immunofluorescence technology, it has high sensitivity and specificity. This technology uses quantum dot labeled antibodies, combined with fluorescence signal amplification mechanism, to accurately detect the IgE antibody concentration of 27 common allergens (such as pollen, dust mites, milk, peanuts, etc.) in whole blood, serum or plasma, with a minimum detection limit as low as 0.1 IU/mL, covering common clinical allergen types. Magnetic particle chemiluminescence method: another innovative technology of Deheng Medical, suitable for high-throughput detection scenarios (such as laboratories in tertiary hospitals), with higher detection flux and automation compatibility, and can be used for; Meet the demand for large-scale screening. Quantitative testing: provides numerical results that are superior to traditional qualitative testing (only displaying“); Positive/Negative; ）Facilitate dynamic monitoring of antibody changes after allergen exposure.Comprehensive and flexible: There are 27 common allergens (including total IgE) in China, and 7 combinations can be flexibly combined.Whole blood compatibility: No need for centrifugation, direct use of fingertip blood samples, especially suitable for children and emergency situations.CCD cleaning technology: With a unique embedded design for CCD cleaning, it effectively reduces false positive interference from CCD.Room temperature storage and transportation: stored at room temperature, no need for cold chain, valid for 18 months.Clinical applicability: Suitable for primary hospitals, clinics, and third-party testing institutions, meeting the equipment requirements of different levels of medical institutions. Deheng Medical's allergen testing products have outstanding performance in the domestic alternative and primary healthcare markets, with fast, accurate, and low-cost as their core competitiveness. Despite facing technological suppression from international brands and fierce competition in the home market, its technological iteration and diversified scene layout are still worth looking forward to. For medical institutions and investors, Deheng's products are currently one of the cost-effective choices in the field of allergy testing in China.     Why conduct full quantification testing for allergens Predicting allergy probability: Quantitative results, more intuitive quantification, help to determine the occurrence of allergy symptoms.More accurate test results: From the perspective of laboratory medicine analysis, quantitative test results have better precision and repeatability.Assessing disease severity: Quantitative results help evaluate the severity of allergic diseases, assist in precise treatment, and guide medication.Evaluating the effectiveness of desensitization therapy: The ratio of specific IgE to total IgE helps to determine the effectiveness of desensitization therapy in patients. Studies have found that patients with sIgE/tIgE>16.2% have relatively better desensitization therapy effects. The reason for choosing quantum dots as labeling materials for allergen detectionExcellent Materials‐ — quantum dotQuantum dots (QDs), also known as nanocrystals, are nanoparticles composed of IV, II-V1, IV-VI, or I-V elements. Quantum dots are generally spherical or quasi spherical in shape, with diameters ranging from 2-20nm. Due to the quantum confinement of electrons and holes, the continuous band structure transforms into a discrete energy level structure with molecular properties, which can emit fluorescence upon excitation. It is an excellent luminescent labeling material discovered in the field of in vitro diagnostic (IVD) reagents in the world so far! Quantum dots, as a labeling material for allergen detection, exhibit significant advantages in sensitivity, stability, and multi index detection capability due to their unique physical and chemical properties. High fluorescence intensity: In the detection of low concentration allergens (such as trace IgE antibodies), quantum dots can provide clearer signals and reduce false negative results.Strong stability: Quantum dots are less prone to photobleaching and can maintain stable fluorescence signals even under prolonged illumination.Multicolor fluorescence compatibility: The emission spectra of quantum dots do not overlap, avoiding signal interference and suitable for high-throughput detection. In allergen omics analysis, dozens of allergens can be detected simultaneously to improve detection efficiency.High sensitivity and specificity: The fluorescence signal of quantum dots can be further amplified through surface modification (such as connecting multiple antibody molecules) to improve detection sensitivity. Quantum dots can provide more reliable quantitative results in low concentration allergen detection. Quantum dots can bind specifically to antibodies or antigens through surface modifications such as carboxyl and amino groups, reducing non-specific adsorption. Reduce false positive rate and improve detection accuracy. Quantum dots are an ideal choice for improving detection performance due to their high fluorescence intensity, stability, multi-color labeling ability, and technical compatibility. Its application not only improves the sensitivity and accuracy of detection, but also promotes the development of multi index joint detection and high-throughput automated detection. With the further maturity of technology and the reduction of costs, the application prospects of quantum dots in allergen detection will be even broader.           reference:Zhang Liying, Zhao Quan The current status of in vitro diagnosis of type I hypersensitivity allergens [J]. Chinese Journal of Rehabilitation Medicine, 2019, 28 (09): 940-941Huang Hongmei, Li Lu, Yan Hailin Quantum dots‐ — Colorful Nanomaterials [J]. Chemistry Education (Chinese and English), 2025, 46 (02): 1-8Wang Jinghua, Liu Congcong, Pan Lu, etc Research progress on diagnosis and treatment of childhood allergies [J]. Chinese Journal of Practical Pediatrics, 2019,34 (11): 954-962Di Lorenzo  G  ,   Mansueto  P  ,   Pacor  ML  , et al.  Evaluation of serum s-IgE/total IgE ratio in predicting clinical response to allergen-specific immunotherapy[J].  J Allergy Clin Immunol,  2009,123(5):1103-1110, 1110.e1-4.